E. Piaggio

TNFR2 blockade promotes anti-tumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion

This study shows that blocking TNFR2 reduces Treg activity and T cell exhaustion in PDAC, with improved efficacy when combined with CD40 agonists.

Ex vivo quantification of anti-tumor T-cell activity upon anti-PD-1 treatment in patient-derived lung tumor-on-chip

This study develops and validates lung-tumor-on-chip platforms to measure ex vivo anti-PD-1 treatment effects on T-cell activity using live imaging and image analysis.

The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier

This study identifies HP1γ as an epigenetic repressor of IFN-γ responsive genes at the gut epithelial barrier, showing its role in dampening immune responses.

Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells

Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue

The paper identifies specialized Tfh1 and Tfh2 subsets driving type-1 and type-2 humoral responses using single-cell transcriptomics and machine learning.

Cellular selectivity of STING stimulation determines priming of tumor-specific T cell responses

This study shows that targeting STING in dendritic cells with cGAMP-VLP enhances tumor-specific T cell responses and synergizes with PD1 blockade for tumor eradication, while synthetic CDN causes systemic T cell activation without specific T cell differentiation.

Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients.

The paper identifies FOLR2+ macrophages in breast cancer that correlate with improved patient survival and co-localize with CD8+ T cells across multiple cancers.

A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system

This study shows that combining anti-ICOS mAb with chemotherapy reduces tumor growth in humanized mice by enhancing CD8+ T cell activity and reducing Treg numbers.

IL-17RA-signaling modulates CD8+ T cell survival and exhaustion during Trypanosoma cruzi infection

This study shows that IL-17RA-signaling supports CD8+ T cell survival and function during Trypanosoma cruzi infection, with its absence leading to increased parasite load and reduced T cell responses.