ImmunologybioRxiv
Cellular selectivity of STING stimulation determines priming of tumor-specific T cell responses
B. Jneid, A. Bochnakian, F. Delisle…·N. Manel
This study shows that targeting STING in dendritic cells with cGAMP-VLP enhances tumor-specific T cell responses and synergizes with PD1 blockade for tumor eradication, while synthetic CDN causes systemic T cell activation without specific T cell differentiation.
DOI 10.1126/sciimmunol.abn6612