Author

R. L. Graham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:variant effect prediction· 2

Frequent Co-Authors

R. S. Baric· 5 shared S. R. Leist· 4 shared L. E. Gralinski· 3 shared M. T. Heise· 3 shared B. L. Yount· 2 shared D. R. Miller· 2 shared E. A. Madden· 2 shared E. S. Winkler· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersMicrobiology

R. S. Baric

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

R. S. Baric, A. Schaefer, S. R. Leist, L. Gralinski, D. Martinez, E. S. Winkler, K. Okuda, P. E. Hawkins, K. L. Gully, R. L. Graham, T. D. Scobey, T. A. Bell, P. Hock, G. D. Shaw, J. F. Loome, , M. T. Ferris

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

bioRxiv · Jun 1, 2022Microbiology

Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species

A. Schafer, L. E. Gralinski, S. R. Leist, E. S. Winkler, B. K. Hampton, M. A. Mooney, K. L. Jensen, R. L. Graham, S. Agnihothram, S. Jeng, S. Chamberlin, T. A. Bell, D. T. Scobey, L. A. VanBlargan, L. B. Thackray, , R. S. Baric

The paper identifies host susceptibility loci for SARS-CoV and SARS-CoV-2 using GWAS and Collaborative Cross datasets, validating CCR9 as a key regulator of severe disease outcomes across species.

bioRxiv · May 14, 2021 · PreprintMicrobiology

Comparative analysis of coronavirus genomic RNA structure reveals conservation in SARS-like coronaviruses

W. Sanders, E. J. Fritch, E. A. Madden, R. L. Graham, H. A. Vincent, M. T. Heise, R. S. Baric, N. J. Moorman

This study identifies conserved RNA secondary structures in SARS-like coronaviruses, suggesting their role in replication and pathogenesis and proposing their disruption as a vaccine strategy.

bioRxiv · Jun 15, 2020 · PreprintMicrobiology

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

A. J. Pruijssers, A. S. George, A. Schäfer, S. R. Leist, L. E. Gralinski, K. H. Dinnon, B. L. Yount, M. L. Agostini, L. J. Stevens, J. D. Chappell, X. Lu, T. M. Hughes, K. L. Gully, D. R. Martinez, A. J. Brown, , T. P. Sheahan

This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.

bioRxiv · Apr 27, 2020Microbiology

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

V. D. Menachery, L. E. Gralinski, H. D. Mitchell, K. H. Dinnon, S. R. Leist, B. L. Yount, R. L. Graham, E. T. McAnarney, K. G. Stratton, A. S. Cockrell, K. Debbink, A. C. Sims, K. M. Waters, R. S. Baric

This study shows that disrupting MERS-CoV NSP16's 2O methyl-transferase activity attenuates viral pathogenesis and provides a live attenuated vaccine platform.

bioRxiv · Aug 8, 2017Microbiology