Author

E. A. Madden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. T. Heise· 5 shared R. S. Baric· 3 shared C. Lim· 2 shared E. Anderson· 2 shared M. S. Diamond· 2 shared N. J. Moorman· 2 shared R. J. Dickmander· 2 shared R. L. Graham· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

M. T. Heise

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

J. W. Guarnieri, M. Topper, K. Beigel, J. A. Haltoom, A. Chadburn, J. Frere, J. An, H. Cope, A. Borczuk, S. Sinha, C. Lim, J. Kim, J. Park, C. Meydan, J. Foox, , K Clark

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

bioRxiv · Oct 8, 2023 · PreprintImmunology

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

R. S. Baric, A. Schaefer, S. R. Leist, L. Gralinski, D. Martinez, E. S. Winkler, K. Okuda, P. E. Hawkins, K. L. Gully, R. L. Graham, T. D. Scobey, T. A. Bell, P. Hock, G. D. Shaw, J. F. Loome, , M. T. Ferris

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

bioRxiv · Jun 1, 2022Microbiology

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

J. B. Case, S. Mackin, J. Errico, Z. Chong, E. A. Madden, B. Guarino, M. A. Schmid, K. Rosenthal, K. Ren, A. Jung, L. Droit, S. A. Handley, P. J. Halfmann, Y. Kawaoka, J. E. Crowe, , M. S. Diamond

This study evaluates the effectiveness of S309 and AZD7442 monoclonal antibodies against Omicron variants in mice, showing reduced lung infection despite decreased neutralization in vitro.

bioRxiv · Mar 17, 2022Microbiology

Nanoformulated Remdesivir with Extremely Low Content of Poly(2-oxazoline) - Based Stabilizer for Aerosol Treatment of COVID-19

J. D. Ramsey, I. E. Stewart, E. A. Madden, C. Lim, D. Hwang, M. T. Heise, A. J. Hickey, A. V. Kabanov

bioRxiv · Jan 21, 2022Bioengineering

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

X. Yang, R. J. Dickmander, A. Bayati, S. A. Taft-Benz, J. L. Smith, C. I. Wells, E. A. Madden, J. W. Brown, E. M. Lenarcic, B. L. Yount, E. Chang, A. D. Axtman, R. S. Baric, M. T. Heise, P. S. McPherson, , T. M. Willson

The paper shows that inhibiting the kinase CSNK2 blocks replication of several beta-coronaviruses, including SARS-CoV-2, by preventing viral entry.

bioRxiv · Jan 3, 2022 · PreprintCell Biology

Comparative analysis of coronavirus genomic RNA structure reveals conservation in SARS-like coronaviruses

W. Sanders, E. J. Fritch, E. A. Madden, R. L. Graham, H. A. Vincent, M. T. Heise, R. S. Baric, N. J. Moorman

This study identifies conserved RNA secondary structures in SARS-like coronaviruses, suggesting their role in replication and pathogenesis and proposing their disruption as a vaccine strategy.

bioRxiv · Jun 15, 2020 · PreprintMicrobiology