Author

R. Lochbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Frick· 2 shared A. Anastasia· 1 shared A. Kleger· 1 shared A. Seidel· 1 shared A.-K. Mittler· 1 shared C. Conzelmann· 1 shared c. Prelli-Bozzo· 1 shared C. Schumann· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

M. Frick

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2 papers

Recent·Most cited

Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo

K. Ernst, A.-K. Mittler, V. Winkelmann, N. Eberhardt, A. Anastasia, M. Sonnabend, R. Lochbaum, J. Wirsching, C. Skerry, N. H. Carbonetti, M. Frick, H. Barth

The paper investigates how host chaperones facilitate pertussis toxin uptake and shows that pharmacological inhibition of these chaperones protects cells from PT toxicity.

bioRxiv · Sep 24, 2020Pharmacology & Toxicology

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

L. Wettstein, C. Conzelmann, J. A. Mueller, T. Weil, R. Gross, M. Hirschenberger, A. Seidel, S. Klute, c. Prelli-Bozzo, F. Zech, N. Preising, G. Fois, R. Lochbaum, P. Knaff, V. Mailaender, , J. Muench

The paper identifies 1-antitrypsin as a specific inhibitor of SARS-CoV-2, showing it blocks viral infection of human airway epithelium at physiological concentrations.

bioRxiv · Jul 2, 2020 · PreprintMicrobiology