Author

S. Klute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3

Frequent Co-Authors

F. Kirchhoff· 3 shared F. Zech· 3 shared C. Conzelmann· 2 shared J. A. Mueller· 2 shared J. Muench· 2 shared K. Sparrer· 2 shared L. Koepke· 2 shared M. Frick· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

F. Kirchhoff

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

R. Nchioua, A. Schundner, S. Klute, S. Noettger, F. Zech, L. Koepke, A. Graf, S. Krebs, H. Blum, D. Kmiec, M. Frick, F. Kirchhoff, K. Sparrer

This study examines IFN sensitivity of SARS-CoV-2 variants, finding Delta remains as sensitive as early isolates, while Alpha, Beta, and Gamma show increased resistance.

bioRxiv · Nov 16, 2021Microbiology

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

M. Hayn, M. Hirschenberger, L. Koepke, J. H. Straub, R. Nchioua, M. H. Christensen, S. Klute, C. Prelli Bozzo, W. Aftab, F. Zech, C. Conzelmann, J. A. Mueller, S. Srinivasachar Badarinarayan, C. M. Stuerzel, I. Forne, , K. M. J. Sparrer

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

bioRxiv · Oct 15, 2020Microbiology

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

L. Wettstein, C. Conzelmann, J. A. Mueller, T. Weil, R. Gross, M. Hirschenberger, A. Seidel, S. Klute, c. Prelli-Bozzo, F. Zech, N. Preising, G. Fois, R. Lochbaum, P. Knaff, V. Mailaender, , J. Muench

The paper identifies 1-antitrypsin as a specific inhibitor of SARS-CoV-2, showing it blocks viral infection of human airway epithelium at physiological concentrations.

bioRxiv · Jul 2, 2020 · PreprintMicrobiology