Author

M. Frick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 3 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. Kirchhoff· 4 shared F. Zech· 4 shared A. Graf· 3 shared A. Schundner· 3 shared D. Kmiec· 3 shared H. Blum· 3 shared L. Koepke· 3 shared R. Nchioua· 3 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

F. Kirchhoff

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The unconventional Myosin-1C augments endothelial secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane

S. El-Mansi, T. P. Mitchell, P. Miklavc, M. Frick, T. D. Nightingale

This study identifies Myosin-1C's role in enhancing endothelial secretion of von Willebrand factor by linking actomyosin machinery to the plasma membrane during exocytosis.

bioRxiv · Aug 11, 2023Cell Biology

The Idiopathic Pulmonary Fibrosis-associated single nucleotide polymorphism rs35705950 is transcribed in a MUC5B PromoterAssociated Long Non-Coding RNA(AC061979.1)

R. Neatu, D. J. Thompson, I. Enekwa, E. C. Schwalbe, G. Fois, M. Frick, P. Braubach, S. A. Moschos

The paper identifies a long non-coding RNA (AC061979.1) associated with the IPF SNP rs35705950 and shows its expression in lung epithelial cells.

bioRxiv · Jan 18, 2022 · PreprintCell Biology

SARS-CoV-2 variants of concern are dependent on IFITM2 for efficient replication in human lung cells

R. Nchioua, A. Schundner, D. Kmiec, C. Prelli Bozzo, F. Zech, L. Koepke, A. Graf, S. Krebs, H. Blum, M. Frick, K. M. J. Sparrer, F. Kirchhoff

The paper was withdrawn due to duplicate submission and is not intended for citation.

bioRxiv · Dec 6, 2021 · PreprintImmunology

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

R. Nchioua, A. Schundner, D. Kmiec, C. Prelli Bozzo, F. Zech, L. Koepke, A. Graf, S. Krebs, H. Blum, M. Frick, K. M. Sparrer, F. Kirchhoff

This study shows that SARS-CoV-2 variants of concern (VOCs) require IFITM2 for efficient replication in human lung cells, with IFITM2 depletion reducing viral RNA and infectious virus production by over four orders of magnitude.

bioRxiv · Nov 17, 2021 · PreprintMicrobiology

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

R. Nchioua, A. Schundner, S. Klute, S. Noettger, F. Zech, L. Koepke, A. Graf, S. Krebs, H. Blum, D. Kmiec, M. Frick, F. Kirchhoff, K. Sparrer

This study examines IFN sensitivity of SARS-CoV-2 variants, finding Delta remains as sensitive as early isolates, while Alpha, Beta, and Gamma show increased resistance.

bioRxiv · Nov 16, 2021Microbiology

Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo

K. Ernst, A.-K. Mittler, V. Winkelmann, N. Eberhardt, A. Anastasia, M. Sonnabend, R. Lochbaum, J. Wirsching, C. Skerry, N. H. Carbonetti, M. Frick, H. Barth

The paper investigates how host chaperones facilitate pertussis toxin uptake and shows that pharmacological inhibition of these chaperones protects cells from PT toxicity.

bioRxiv · Sep 24, 2020Pharmacology & Toxicology

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

L. Wettstein, C. Conzelmann, J. A. Mueller, T. Weil, R. Gross, M. Hirschenberger, A. Seidel, S. Klute, c. Prelli-Bozzo, F. Zech, N. Preising, G. Fois, R. Lochbaum, P. Knaff, V. Mailaender, , J. Muench

The paper identifies 1-antitrypsin as a specific inhibitor of SARS-CoV-2, showing it blocks viral infection of human airway epithelium at physiological concentrations.

bioRxiv · Jul 2, 2020 · PreprintMicrobiology

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in an iPSC-derived air-liquid interface model

E. Schruf, V. Schroeder, H. Q. Le, T. Schoenberger, D. Raedel, E. L. Stewart, K. Fundel-Clemens, T. Bluhmki, S. Weigle, M. Schuler, M. J. Thomas, R. Heilker, M. J. Webster, M. Dass, M. Frick, , J. P. Garnett

This study develops an iPSC-derived air-liquid interface model to mimic IPF-related bronchiolization and shows IPF-RC stimulation alters ATII differentiation and transcriptome profiles.

bioRxiv · Nov 4, 2019Cell Biology