BiochemistrybioRxiv
Nicotinamide mononucleotide (NMN) de-amidation by host-microbiome interactions
L.-J. Kim, T. J. Chalmers, R. Madawala…·L. E. Wu
This study shows orally delivered NMN undergoes deamidation and incorporation into mammalian tissue via the de novo pathway, with microbiome disruption reducing this process and increasing gut NAD+ availability.
DOI 10.1002/1873-3468.14698