Author

D. A. Sinclair

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Microbiology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:machine learning (classical)· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

A. E. Kane· 3 shared S. J. Mitchell· 3 shared J. R. Mitchell· 2 shared L. E. Wu· 2 shared M. B. Schultz· 2 shared M. R. MacArthur· 2 shared A. Aitken· 1 shared A. Andren· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. E. Kane

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Author profile →

6 papers

Recent·Most cited

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

A. E. Kane, K. Chellappa, M. B. Schultz, M. Arnold, J. Li, J. Amorim, C. Diener, D. Zhu, S. J. Mitchell, P. T. Griffin, X. Tian, C. Petty, R. Conway, K. Walsh, L. Shelerud, , D. A. Sinclair

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

bioRxiv · Jun 21, 2024 · PreprintPharmacology & Toxicology

A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice

L. Pernomian, E. W. Waigi, V. Nguyen, A. Mohammed, T. J. Costa, M. T. Fontes, J. L. Kubinak, A. Aitken, V. C. Biancardi, D. A. Sinclair, C. G. McCarthy, Y. Wang, W. Tan, C. F. Wenceslau

This study shows that reprogramming endothelial cells in hypertensive mice with OSK factors reduces blood pressure by inhibiting EndMT and vascular damage.

bioRxiv · May 20, 2024Physiology

Gut Microbiota predicts Healthy Late-life Aging in Male Mice

S. Ke, S. J. Mitchell, M. R. MacArthur, A. E. Kane, D. A. Sinclair, E. M. Venable, K. S. Chadaideh, R. N. Carmody, F. Grodstein, J. R. Mitchell, Y.-Y. Liu

This study shows that gut microbiota signatures from young mice can predict healthy aging in older mice under calorie restriction.

bioRxiv · Jun 22, 2021Microbiology

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

A. H. Guo, R. K. Baliira, M. E. Skinner, S. Kumar, A. Andren, L. Zhang, S. Michan, N. J. Davis, M. W. Maccani, S. Day, D. A. Sinclair, C. A. Lyssiotis, A. B. Stein, D. B. Lombard

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

bioRxiv · Jun 15, 2021Pathology

Nicotinamide mononucleotide (NMN) de-amidation by host-microbiome interactions

L.-J. Kim, T. J. Chalmers, R. Madawala, G. C. Smith, A. Das, E. W. K. Poon, J. Wang, S. P. Tucker, D. A. Sinclair, L.-E. Quek, L. E. Wu

This study shows orally delivered NMN undergoes deamidation and incorporation into mammalian tissue via the de novo pathway, with microbiome disruption reducing this process and increasing gut NAD+ availability.

bioRxiv · Sep 10, 2020Biochemistry

Age and life expectancy clocks based on machine learning analysis of mouse frailty

M. B. Schultz, A. E. Kane, S. J. Mitchell, M. R. MacArthur, E. Warner, J. R. Mitchell, S. E. Howlett, M. S. Bonkowski, D. A. Sinclair

This paper develops two machine learning clocks to predict chronological age and life expectancy in mice using Frailty Indices, showing their accuracy in predicting lifespan and intervention efficacy.

bioRxiv · Dec 20, 2019Physiology