Author

D. Long

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. Williamson· 2 shared E. de Wit· 2 shared G. Saturday· 2 shared H. C. Crawford· 2 shared H.-J. Wen· 2 shared J. Port· 2 shared J. Schulz· 2 shared M. A. Quinn· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

B. Williamson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

D. J. Salas-Escabillas, M. T. Hoffman, J. S. Moore, S. M. Brender, H.-J. Wen, S. Benitz, E. T. Davis, D. Long, A. M. Wombwell, N. G. Steele, R. C. Sears, I. Matsumoto, K. E. DelGiorno, H. C. Crawford

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

bioRxiv · Feb 12, 2024Cancer Biology

Dichloroacetate improves systemic energy balance and feeding behavior during sepsis

T. Oh, M. Zabalawi, S. Jain, D. Long, P. Stacpoole, C. McCall, M. A. Quinn

This study shows that dichloroacetate improves energy balance and feeding behavior in sepsis by reversing metabolic dysfunctions and glycine deficiency.

bioRxiv · Jul 21, 2021Immunology

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

R. Fischer, N. van Doremalen, D. Adney, C. Yinda, J. Port, M. Holbrook, J. Schulz, B. Williamson, T. Thomas, K. Barbian, S. Anzick, S. Ricklefs, B. Smith, D. Long, C. Martens, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

bioRxiv · Mar 11, 2021Microbiology

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

R. Mainali, M. Zabalwi, D. Long, N. Buechler, E. Quillen, C.-C. Key, X. Zhu, J. Parks, C. Furdui, P. Stacpoole, J. Martinez, C. E. McCall, M. A. Quinn

This study shows dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction by targeting mitochondrial PDC/PDK energy homeostasis in a mouse model.

eLife · Feb 22, 2021Peer-reviewedImmunology

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

S. A. Kerk, L. Lin, A. L. Myers, Y. Zhang, J. A. Jimenez, P. Sajjakulnukit, B. S. Nelson, B. Chen, A. Robinson, G. Thurston, S. B. Kemp, N. G. Steele, M. T. Hoffman, H.-J. Wen, D. Long, , C. A. Lyssiotis

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

bioRxiv · Aug 7, 2020Cancer Biology

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

N. van Doremalen, T. Lambe, A. Spencer, S. Belij-Rammerstorfer, J. Purushotham, J. Port, V. Avanzato, T. Bushmaker, A. Flaxman, M. Ulaszewska, F. Feldmann, E. Allen, H. Sharpe, J. Schulz, M. Holbrook, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

bioRxiv · May 13, 2020 · PreprintMicrobiology