Cell BiologybioRxiv
D-mannose ameliorates age-associated cellular senescence in the bladder urothelium and NLRP3/Gasdermin/IL-1β -driven pyroptotic epithelial cell shedding
C. S. Joshi, A. M. Salazar, C. Wang…·I. U. Mysorekar
This study shows that D-mannose reduces age-related bladder urothelial senescence and pyroptotic cell shedding in mice by improving autophagy and reversing SASP.
DOI 10.1016/j.devcel.2023.11.017