Author

R. S. Bindra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Cui· 1 shared A. Huttner· 1 shared G. A. Breuer· 1 shared G. P. Gupta· 1 shared H.-W. Suh· 1 shared J. Bezney· 1 shared J. Purcell· 1 shared N. R. Fons· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Cui

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Author profile →

3 papers

Recent·Most cited

PARG inhibition induces nuclear aggregation of PARylated PARP1

S. Paradkar, J. Purcell, A. Cui, S. Friedman, R. Sundaram, R. B. Jensen, R. S. Bindra

This study shows that PARG inhibition causes PARP1 to aggregate in the nucleus, leading to mis-localization and non-apoptotic cell death.

bioRxiv · Aug 12, 2023Cancer Biology

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

Y. Wang, S. Malik, H.-W. Suh, Y. Xiao, Y. Deng, R. Fan, A. Huttner, R. S. Bindra, W. M. Saltzman, R. Bahal

This study develops anti-seed PNAs targeting oncomiRs 10b and 21 for GBM therapy, showing improved tumor growth inhibition and survival in mice.

Science Advances · Feb 10, 2023Peer-reviewedCancer Biology

CRISPR screening identifies novel PARP inhibitor classification based on distinct base excision repair pathway dependencies

G. A. Breuer, J. Bezney, N. R. Fons, R. K. Sundaram, W. Feng, G. P. Gupta, R. S. Bindra

This study identifies novel PARP inhibitor classifications based on distinct base excision repair pathway dependencies revealed through CRISPR screening, showing that PARP trapping and catalytic inhibition are not the only factors affecting their biological activity.

bioRxiv · Oct 18, 2020 · PreprintCancer Biology