Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition
J. van Loosdregt, J. Peeters, A. Boltjes, R. Scholman, S. Vervoort, P. Coffer, M. Mokry, B. Vastert, F. van Wijk
The paper investigates epigenetic changes in monocytes from JIA patients and shows JAK inhibition can reverse disease-related gene expression.
bioRxiv · Nov 20, 2021 · PreprintImmunology