Author

B. Vastert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

F. van Wijk· 3 shared J. van Loosdregt· 3 shared L. Lutter· 2 shared M.-F. Mashreghi· 2 shared P. Coffer· 2 shared P. Maschmeyer· 2 shared A. Boltjes· 1 shared A. Mazzoni· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

F. van Wijk

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Author profile →

4 papers

Recent·Most cited

Glycolytic reprogramming shapes the epigenetic landscape of activated CD4+ T Cells in Juvenile Idiopathic Arthritis

E. Mocholi, T. Chalkiadakis, C. Gulersonmez, E. Stigter, B. Vastert, J. van Loosdregt, S. Prekovic, P. Coffer

This study shows that glycolytic reprogramming in JIA CD4+ T cells drives epigenetic changes linked to inflammation, with potential therapeutic implications.

bioRxiv · Feb 14, 2024 · PreprintImmunology

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

L. Lutter, M. M. van der Wal, E. C. Brand, P. Maschmeyer, B. Vastert, M.-F. Mashreghi, J. van Loosdregt, F. van Wijk

This study identifies functional heterogeneity in human regulatory T-cells within inflamed arthritic joints using single-cell sequencing and flow cytometry.

bioRxiv · Feb 18, 2022Immunology

Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition

J. van Loosdregt, J. Peeters, A. Boltjes, R. Scholman, S. Vervoort, P. Coffer, M. Mokry, B. Vastert, F. van Wijk

The paper investigates epigenetic changes in monocytes from JIA patients and shows JAK inhibition can reverse disease-related gene expression.

bioRxiv · Nov 20, 2021 · PreprintImmunology

Antigen-driven PD1+Tox+Eomes+ and PD1+Tox+BHLHE40+ synovial T lymphocytes regulate chronic inflammation in situ

P. Maschmeyer, G. A. Heinz, C. Skopnik, L. Lutter, A. Mazzoni, F. Heinrich, S. L. von Stuckrad, L. E. Wirth, C. L. Tran, R. Riedel, K. Lehmann, I. Sakwa, R. Cimaz, F. Giudici, M. A. Mall, , M.-F. Mashreghi

The paper identifies distinct subpopulations of synovial T lymphocytes in JIA patients using single-cell RNA-sequencing and shows their roles in regulating chronic inflammation.

bioRxiv · Dec 27, 2019 · PreprintImmunology