Author

A. Boltjes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

F. van Wijk· 3 shared J. van Loosdregt· 2 shared M. Mokry· 2 shared S. Vastert· 2 shared A. A. K. Samat· 1 shared A. Pandit· 1 shared A. Petrelli· 1 shared B. Castelijns· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

F. van Wijk

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Author profile →

3 papers

Recent·Most cited

Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

G. Mijnheer, N. H. Servaas, J. Y. Leong, A. Boltjes, E. Spierings, P. Chen, L. Lai, A. Petrelli, S. Vastert, R. J. De Boer, S. Albani, A. Pandit, F. van Wijk

The paper identifies persistent, antigen-specific T cell clones in JIA joints and circulation, suggesting antigen-driven expansion of both Tregs and Teffector cells.

bioRxiv · Feb 10, 2022Immunology

Functional Specialization of Specific DC Subsets in the Synovial Fluid of JIA Patients

A. Boltjes, A. A. K. Samat, M. Plantinga, M. Mokry, B. Castelijns, J. Swart, S. Vastert, M. Creyghton, S. Nierkens, J. van Loosdregt, F. van Wijk

This study identifies functional specialization of dendritic cell subsets in synovial fluid of JIA patients, showing cDC2 and monocytes are pro-inflammatory while cDC1 remains quiescent.

bioRxiv · Feb 9, 2022 · PreprintImmunology

Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition

J. van Loosdregt, J. Peeters, A. Boltjes, R. Scholman, S. Vervoort, P. Coffer, M. Mokry, B. Vastert, F. van Wijk

The paper investigates epigenetic changes in monocytes from JIA patients and shows JAK inhibition can reverse disease-related gene expression.

bioRxiv · Nov 20, 2021 · PreprintImmunology