M. Mokry

IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration

This study shows IFNγ reprograms intestinal epithelial organoids to secrete CXCL11, which enhances T cell migration without affecting T cell activation.

Colchicine promotes atherosclerotic plaque stability independently of inflammation

This study shows colchicine stabilizes atherosclerotic plaques by converting harmful SMC-derived cells into protective myofibroblast-like cells, independent of its anti-inflammatory effects.

Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function

This study shows chemotherapy-induced intestinal damage promotes T cell activation and trafficking via galectin-9, linking epithelial injury to GVHD pathogenesis.

Human primary plaque cell cultures to study mechanisms of atherosclerosis

This study isolates and cultures primary human plaque smooth muscle cells to serve as an in vitro model for studying atherosclerosis mechanisms.

Functional Specialization of Specific DC Subsets in the Synovial Fluid of JIA Patients

This study identifies functional specialization of dendritic cell subsets in synovial fluid of JIA patients, showing cDC2 and monocytes are pro-inflammatory while cDC1 remains quiescent.

Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition

The paper investigates epigenetic changes in monocytes from JIA patients and shows JAK inhibition can reverse disease-related gene expression.

Locational memory of macrovessel vascular cells is transcriptionally imprinted

The paper identifies transcriptional patterns in adult canine vascular cells that persist in culture, suggesting a molecular memory of their original location.

Human placental bed transcriptomic profiling reveals inflammatory activation of endothelial cells in preeclampsia

The paper identifies inflammatory activation of endothelial cells in preeclampsia through transcriptomic profiling and systemic biomarker analysis.

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

The paper identifies a conserved human effector Treg signature through transcriptomic and epigenetic analysis, showing overlap with tumor-infiltrating Treg and environment-driven adaptations.

Human regulatory T cells at the maternal-fetal interface show functional site-specific adaptation with tumor-infiltrating-like features

This study identifies a distinct transcriptional profile of uterine regulatory T cells at the maternal-fetal interface, showing features similar to tumor-infiltrating Tregs.