Author

R. Twaddle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

C. L. Mora· 3 shared J. Angeles· 3 shared J. B. Nice· 3 shared K. Elliott· 3 shared M. Cacciottolo· 3 shared m. sun· 3 shared M. Young· 3 shared Y. Li· 3 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

C. L. Mora

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multivalent Exosome based protein vaccine: a "mix and match" approach to epidemic viruses' challenges.

M. Cacciottolo, L.-E. Hsieh, Y. Li, M. J. LeCalire, J. B. Nice, R. Twaddle, C. L. Mora, M. Young, J. Angeles, C. Lau, C. Jin, K. Elliott, m. sun

This study develops a multivalent exosome-based vaccine platform that effectively induces strong immune responses against multiple viruses using minimal protein and no adjuvant.

bioRxiv · Jul 13, 2023Immunology

Nanograms of SARS-CoV-2 Spike Protein Delivered by Exosomes Induce Potent Neutralization of Both Delta and Omicron Variants.

M. Cacciottolo, Y. Li, J. B. Nice, M. J. LeClaire, R. Twaddle, C. L. Mora, S. Y. Adachi, M. Young, J. Angeles, K. Elliott, M. Sun

This study demonstrates that exosomes delivering nanogram amounts of SARS-CoV-2 Spike protein induce potent neutralization against Delta and Omicron variants and enhance T cell responses.

bioRxiv · Mar 20, 2023Immunology

Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins

M. Cacciottolo, J. B. Nice, Y. Li, M. J. LeClaire, R. Twaddle, C. L. Mora, S. Y. Adachi, E. R. Chin, M. Young, J. Angeles, K. Elliott, M. Sun

This paper develops a multivalent exosome-based vaccine using nanogram doses of SARS-CoV-2 proteins without adjuvant, showing strong immune responses and cross-reactivity against variants.

bioRxiv · Jan 10, 2023 · PreprintImmunology