M. Young

From manual analysis to automation: scaling passive acoustic monitoring for the endangered Saimaa ringed seals

The paper develops automated methods for detecting and characterizing knocking vocalizations of Saimaa ringed seals using passive acoustic monitoring, achieving high accuracy comparable to manual analysis.

A Fast and Low-Cost Approach for Binding Mode Validation of AI-Designed Therapeutics

The paper introduces HDX FineMapping, a method that achieves full sequence coverage and epitope characterization for AI-designed therapeutics without requiring mutations or crystallization.

Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

This study examines how the loss of IP3R calcium signaling affects transcriptional regulation and identifies three key adaptations in IP3R TKO cells.

Switching circuits: Modulating NK cell response to TGF-β using novel receptors

This study identifies novel switch receptors for NK cells that enhance cytotoxicity and persistence in the presence of TGF-β through a pooled screening approach.

TRAFfic signals: High-throughput CAR discovery in NK cells reveals novel TRAF-binding endodomains that drive enhanced persistence and cytotoxicity

This study identifies TRAF-binding endodomains that enhance CAR NK cell persistence and cytotoxicity through high-throughput screening.

Multivalent Exosome based protein vaccine: a "mix and match" approach to epidemic viruses' challenges.

This study develops a multivalent exosome-based vaccine platform that effectively induces strong immune responses against multiple viruses using minimal protein and no adjuvant.

Nanograms of SARS-CoV-2 Spike Protein Delivered by Exosomes Induce Potent Neutralization of Both Delta and Omicron Variants.

This study demonstrates that exosomes delivering nanogram amounts of SARS-CoV-2 Spike protein induce potent neutralization against Delta and Omicron variants and enhance T cell responses.

Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins

This paper develops a multivalent exosome-based vaccine using nanogram doses of SARS-CoV-2 proteins without adjuvant, showing strong immune responses and cross-reactivity against variants.

Investigating the role of binding free energy, binding affinity and antibody escape in the evolution of SARS-CoV-2 spike protein.

This study analyzes the evolution of SARS-CoV-2 spike protein over time, showing increased antibody evasion and stronger RBD-ACE2 binding.

Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX

This paper determines the structure of Tpp49Aa1 using MHz-SFX and investigates its interaction with Cry48Aa1, expanding its known target range to include additional mosquito species.

Antibodies control metabolism by regulating insulin homeostasis

This study identifies anti-insulin IgM antibodies that regulate insulin homeostasis by counteracting neutralizing IgG antibodies, preventing blood glucose dysregulation.

Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing

This paper develops a platform to independently control cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing for optoelectronic tuning.