A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms
F. Chen, Q. Wang, M. Xiao…·Y. Zhang
The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.