Author

D. Lou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

L. Fan· 3 shared K. Chen· 2 shared Y. Zhang· 2 shared Y. Zhu· 2 shared A. A. Ferguson· 1 shared C. Byersdorfer· 1 shared C. Erb· 1 shared C. Ge· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

L. Fan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Monocyte production of C1q potentiates CD8+ T cell effector function following respiratory viral infection

T. Eddens, O. B. Parks, D. Lou, L. Fan, J. Sojati, M. J. Ramsey, L. Schmitt, C. M. Salgado, M. Reyes-Mugica, T. D. Oury, C. Byersdorfer, K. Chen, J. V. Williams

This study shows that monocyte-produced C1q enhances CD8+ T cell function during respiratory viral infections, as demonstrated in mice and human samples.

bioRxiv · Jun 4, 2023Immunology

A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms

F. Chen, Q. Wang, M. Xiao, D. Lou, R. Wufur, S. Hu, Z. Zhang, Y. Wang, Y. Zhang

The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.

bioRxiv · Nov 22, 2022 · PreprintCell Biology

Spermidine dampens inflammation by directly inhibiting Th17 cytokine production through a PRDX1 associated antioxidant pathway

J. Luo, Y. J. Kim, X. An, L. Fan, C. Erb, D. Lou, Y. Yao, A. A. Ferguson, Y. Pan, K. Chen

This study shows spermidine directly inhibits Th17 cytokine production via PRDX1-dependent antioxidant activity, reducing lung inflammation in mouse models.

bioRxiv · Aug 31, 2021Immunology

iRhom2 serves as a facilitator in obesity by enhancing adipose inflammation and insulin resistance

M. Xu, C. Ge, Y. Qin, D. Lou, Q. Li, J. Feng, Y. Wu, L. Hu, P. Huang, J. Tan

This study identifies iRhom2 as a key regulator that promotes obesity-associated metabolic disorder by enhancing adipose inflammation and insulin resistance.

bioRxiv · Apr 5, 2019 · PreprintPathology

Arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in low-dose exposed mouse embryonic fibroblast cells

Y. Zhu, Y. Li, D. Lou, Y. Gao, J. Yu, D. Kong, Q. Zhang, Y. Jia, H. Zhang, Z. Wang

This study shows arsenite exposure reduces p300 and H3K27ac at enhancers in MEF cells, affecting gene expression and potentially contributing to arsenic-related disease.

Toxicology and Applied Pharmacology · Oct 1, 2018Peer-reviewedPharmacology & Toxicology

A Novel AuNPs-based Glucose Oxidase Mimic with Enhanced Activity and Selectivity Constructed by Molecular Imprinting and O2-Containing Nanoemulsion Embedding

L. Fan, H. Wu, D. Lou, X. Zhang, Y. Zhu, N. Gu, Y. Zhang

Advanced Materials Interfaces · Sep 12, 2018Peer-reviewedBiochemistry