M. Xiao

Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model

This study uses a CRISPR-dCas9 model to investigate the BFB cycle, revealing increased DNA damage, chromosome fusions, and involvement of DNA repair pathways in ITCB formation.

Targeting the Atypical Chemokine Receptor 2 (ACKR2) improves the benefit of anti-PD-1 immunotherapy in melanoma

This study shows that targeting ACKR2 enhances anti-PD-1 immunotherapy efficacy in melanoma by improving the tumor microenvironment and immune cell infiltration.

Signal-regulated unmasking of the nuclear localization motif in the PAS domain regulates the nuclear translocation of PASK.

This study identifies a mechanism by which PASK's nuclear translocation is regulated by the interaction between its PAS-A domain and a PIM motif, which is modulated by metabolic signals.

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms

The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.

Different inhibition of Nrf2 by two Keap1 isoforms α and β to shape malignant behaviour of human hepatocellular carcinoma

This study investigates how two Keap1 isoforms, α and β, differentially inhibit Nrf2 and influence malignant behaviors in hepatocellular carcinoma.

clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ

clampFISH 2.0 enables rapid, scalable detection of multiple RNA species in single cells and tissue sections by improving signal amplification and reducing time and cost.

Genomic characterization of four novel bacteriophages infecting the clinical pathogen Klebsiella pneumoniae

The paper isolates and sequences four novel bacteriophages infecting Klebsiella pneumoniae, revealing low sequence identity to known phages and potential new DNA packaging mechanisms and protein clades.

A water-reward task assay for evaluating mouse mutualistic cooperative behavior

This paper introduces a water-reward task assay to quantify mutualistic cooperative behavior in mice and provides detailed procedures for its implementation.

Elevated concentration and nitrogen addition affects responses of foliar phosphorus fractions in invasive species to increased phosphorus supply

The paper examines how elevated CO2 and nitrogen addition influence foliar phosphorus fractions in invasive and native species under varying phosphorus supplies.

Characterization of the gut DNA and RNA viromes in a cohort of Chinese residents and visiting Pakistanis

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

Long non-coding RNA LINC00152 plays an oncogenic role via targeting STAT3 and c-MYC signaling in esophageal adenocarcinoma

This study investigates LINC00152's role in esophageal adenocarcinoma, finding it promotes tumor progression via STAT3 and c-MYC signaling and suggests it as a biomarker and therapeutic target.

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

Genome rearrangements induce biofilm formation in Escherichia coli C, an old model organism with a new application in biofilm research

This paper presents the complete genome of E. coli C, identifies genomic differences linked to biofilm formation, and shows its potential as a model for biofilm research.