ImmunologybioRxivPreprint
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
Karin Gustafsson, Catherine Rhee, Vanessa Frodermann…·David T. Scadden
This study shows that anti-CD45-ADC clears tissue-resident myeloid cells, enabling efficient replacement with donor cells and reducing atherosclerotic plaque burden.
DOI 10.1101/2023.09.05.556397