Non-viral CRISPR/Cas9 Mutagenesis for Streamlined Generation of Mouse Lung Cancer Models
I. Lara-Saez, A. Mencia, E. Recuero, Y. Li, M. Garcia, M. Oteo, M. I. Gallego, A. B. Enguita, D. de Prado-Verdun, S. A, W. Wang, R. Garcia-Escudero, R. Murillas, M. Santos
This paper introduces a non-viral CRISPR/Cas9 method using cationic polymers to generate mouse lung cancer models by inactivating tumor suppressor genes, enabling rapid and flexible hypothesis testing.
bioRxiv · Dec 21, 2023 · PreprintCancer Biology