BBB pathophysiology independent delivery of siRNA in traumatic brain injury
W. Li, J. Qiu, X.-L. Li, S. Aday, J. Zhang, G. Conley, J. Xu, R. Langer, R. Mannix, J. M. Karp, N. Joshi
This paper develops a nanoparticle platform for BBB-independent siRNA delivery in TBI, achieving higher brain accumulation and gene silencing through surface chemistry and coating density modulation.
bioRxiv · Jun 26, 2020Bioengineering