Cancer BiologybioRxivPreprint
Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer
M. Kathiresan, S. Animesh, R. Morris…·W. Haas
The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.
DOI 10.1101/2023.05.04.539299