Author

W. Haas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Assay:proteomics· 6 Research Focus:cell type annotation· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. Kreuzer· 4 shared D. A. Haber· 3 shared R. Morris· 3 shared S. Maheswaran· 3 shared B. S. Wittner· 2 shared D. T. Ting· 2 shared M. Sade-Feldman· 2 shared T. D. Dubash· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCancer Biology

J. Kreuzer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.

E. Horwitz, T. D. Dubash, A. Szabolcs, B. S. Wittner, J. Kreuzer, R. Morris, A. Bardia, B. Chirn, D. Wiley, D. Che, H. C. Russel, X. I. H. Lopez, D. B. Fox, E. Antmen, D. T. Ting, , D. A. Haber

This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.

bioRxiv · Feb 20, 2024 · PreprintCancer Biology

Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer

M. Kathiresan, S. Animesh, R. Morris, J. Kreuzer, P. Krushna, L. Shi, J. Merritt, X. Yin, C. H. Benes, N. Bardeesy, W. Haas

The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.

bioRxiv · May 4, 2023 · PreprintCancer Biology

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

C. Li, M. U. Syed, A. Nimbalkar, Y. Shen, C. Fraser, Z. Inde, X. Qin, J. Ouyang, J. Kreuzer, S. E. Clark, G. E. Kelley, E. Hensley, A. Oh, M. Walcott, R. Morris, , A. N. Hata

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

bioRxiv · Sep 29, 2022 · PreprintCancer Biology

Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

B. P. Boribong, T. J. LaSalle, Y. C. Bartsch, F. Ellett, M. E. Loiselle, J. P. Davis, A. L. K. Gonye, S. Hajizadeh, J. Kreuzer, S. Pillai, W. Haas, A. G. Edlow, A. Fasano, G. Alter, D. Irimia, , L. M. Yonker

The paper identifies neutrophil activation and NET formation in MIS-C linked to SARS-CoV-2 immune complexes, differing from acute pediatric COVID-19.

bioRxiv · Dec 18, 2021Immunology

Improving tuberculosis surveillance by detecting international transmission using publicly available whole-genome sequencing data

A. Sanchini, C. Jandrasits, J. Tembrockhaus, T. A. Kohl, C. Utpatel, F. P. Maurer, S. Niemann, W. Haas, B. Y. Renard, S. Kroeger

This study uses global whole-genome sequencing data to identify international tuberculosis transmission clusters, improving surveillance by connecting cases across countries.

Eurosurveillance · Jan 14, 2021Peer-reviewedMicrobiology

Single cell proteomics of tumor compartments identifies differential kinase activities defining sensitivity to mTOR-PI3-kinase inhibition

N. M. Karabacak, Y. Zheng, T. D. Dubash, R. Burr, D. S. Micalizzi, B. S. Wittner, D. F. Wiley, V. Comaills, E. Emmons, K. Niederhoffer, U. Ho, L. Nieman, W. Haas, S. L. Stott, D. T. Ting, , S. Maheswaran

The paper uses single cell proteomics to identify kinase activity differences in tumor compartments, showing how they affect sensitivity to mTOR-PI3K inhibition.

bioRxiv · Jan 6, 2021 · PreprintCancer Biology

Obtusaquinone is a cysteine modifying compound that targets Keap1 for degradation

c. E. badr, C. C. da Hora, A. Kirov, R. Amante, E. Fitzsimons, J. W. Chen, A. E. Nibbs, I. Nakano, E. Tabet, N. Chiu, W. Haas, R. Mazitschek, B. A. Tannous

This study identifies Obtusaquinone as a cysteine-modifying compound that targets Keap1 for degradation, activating the Nrf2 pathway through proteasomal degradation.

ACS Chemical Biology · Apr 27, 2020Peer-reviewedCancer Biology

A post-transcriptional program of chemoresistance by AU-rich elements and TTP

S. Lee, D. Micalizzi, S. S. Truesdell, S. I. Bukhari, M. Boukhali, J. Lombardi-Story, Y. Kato, I. Dey-Guha, B. T. Nicholson, M.-K. Choo, D. T. Myers, D. Lee, M. A. Mazzola, R. Raheja, A. Langenbucher, , S. Vasudevan

This study identifies a post-transcriptional mechanism of chemoresistance in leukemia involving AU-rich elements and TTP regulation.

bioRxiv · May 3, 2019 · PreprintCancer Biology