Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma
W. Floyd, M. Pierpoint, C. Su, L. Luo, K. Deland, A. J. Wisdom, D. Zhu, Y. Ma, S. B. DeWitt, N. T. Williams, J. A. Somarelli, D. L. Corcoran, W. C. Eward, D. M. Cardona, D. G. Kirsch
This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.
Journal of Clinical Investigation · Jul 3, 2023Peer-reviewedCancer Biology