Author

M. Pierpoint

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. J. Wisdom· 3 shared D. G. Kirsch· 3 shared L. Luo· 3 shared W. Floyd· 3 shared Y. Ma· 3 shared C. Su· 2 shared N. T. Williams· 2 shared A. L. Lazarides· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. J. Wisdom

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3 papers

Recent·Most cited

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

C. Su, C. L. Kent, M. Pierpoint, W. Floyd, L. Luo, N. T. Williams, Y. Ma, B. Peng, A. L. Lazarides, A. Subramanian, J. E. Himes, V. M. Perez, R. D. Hernansaiz-Ballesteros, K. E. Roche, J. L. Modliszewski, , D. G. Kirsch

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

bioRxiv · Jan 3, 2024 · PreprintCancer Biology

Loss of function of Atrx leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma

M. Pierpoint, W. Floyd, A. J. Wisdom, L. Luo, Y. Ma, M. S. Waitkus, D. G. Kirsch

This study shows that loss of Atrx in a mouse sarcoma model activates the ALT telomere maintenance pathway independently of telomerase, leading to telomere instability and APB formation.

bioRxiv · Nov 6, 2023 · PreprintCancer Biology

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

W. Floyd, M. Pierpoint, C. Su, L. Luo, K. Deland, A. J. Wisdom, D. Zhu, Y. Ma, S. B. DeWitt, N. T. Williams, J. A. Somarelli, D. L. Corcoran, W. C. Eward, D. M. Cardona, D. G. Kirsch

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

Journal of Clinical Investigation · Jul 3, 2023Peer-reviewedCancer Biology