K. Schenke-Layland

This study shows that targeting MMP-13 prevents aortic aneurysm formation in Marfan mice by reducing collagen degradation and BMP activity.

The paper profiles proteins in breast carcinomas to identify immune-suppressive factors and signatures linked to patient outcomes.

This paper develops a 3D patient-derived microtumor platform to identify therapeutic vulnerabilities in ovarian cancer by testing drug responses and immune cell interactions.

This study uses histology, immunohistochemistry, and Raman microspectroscopy to analyze inflammatory and regenerative processes in bioresorbable pulmonary valves in sheep over 24 months.

This paper introduces a human-based, immunocompetent WAT-on-chip model that recapitulates adipose tissue heterogeneity and functions for metabolic research and personalized medicine.

This study shows that loss of FH in RPE cells causes retinal degeneration in a co-culture model with porcine retinal explants, with rod cells being the first to degenerate.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

The paper develops NeutrobodyPlex, a multiplex assay using bivalent nanobodies to analyze neutralizing antibodies against SARS-CoV-2 in patient sera.

The paper introduces a Ca2+ biosensor based on a fluorescent protein fused with collagen-binding domains, demonstrating its use in 3D tissue models and FLIM microscopy.

The paper develops a WAT-on-a-chip system to study human white adipose tissue function and drug responses in obesity and diabetes.

This study develops a retina-on-a-chip model using hiPSC-derived retinal cells to recapitulate retinal interactions and test drug effects.