ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination
H. Li, S. Chatla, X. Liu, Z. Tian, U. Vekariya, P. Wang, D. Kim, S. Octaviani, Z. Lian, G. Morton, Z. Feng, D. Yang, K. Sullivan-Reed, W. Childers, X. Yu, , J. Huang
This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.
bioRxiv · Sep 29, 2022 · PreprintCancer Biology