Author

Z. Lian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1 Cell Biology· 1 Pathology· 1 Physiology· 1

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:deep learning· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Assay:imaging· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

A. R. Cox· 2 shared C. Coarfa· 2 shared D. A. Bader· 2 shared D. Kim· 2 shared G. Liu· 2 shared H. Han· 2 shared H. Li· 2 shared H. Wu· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersPhysiology

A. R. Cox

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

M. Chen, Y. Zhao, X. Xu, X. Zhang, J. Zhang, S. Wu, Z. Liu, Y. Yuan, X. Guo, S. Qi, G. Yi, S. Wang, H. Li, A. Wu, G. Liu, , Z. Lian

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

eLife · Oct 4, 2024Peer-reviewedCell Biology

Label-Free Melanoma Phenotype Classification Using Artificial Intelligence-Based Morphological Profiling

E. Lattmann, A. Jovic, J. Kim, T. Pham, C. Corona, Z. Lian, K. Saini, M. Ray, V. Lu, A. Tastanova, S. C. Boutet, M. P. Levesque

This paper develops an AI-based classifier to classify melanoma cell phenotypes using morphology, validated by scRNA-Seq, showing morphology correlates with phenotypic states.

bioRxiv · Jun 28, 2024 · PreprintCancer Biology

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

A. Mavropoulos, C. Johnson, V. Lu, J. Nieto, E. Schneider, K. Saini, M. L. Phelan, L. Hsie, M. Wang, J. Cruz, J. Mei, J. Kim, Z. Lian, N. Li, S. C. Boutet, , J. Rao

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

bioRxiv · Jan 24, 2023Pathology

Deep learning-based predictive identification of functional subpopulations of hematopoietic stem cells and multipotent progenitors

S. Wang, J. Han, J. Huang, Y. Shi, Y. Zhou, D. Kim, M. K. Islam, J. Zhou, O. Ostrovsky, C. Li, Z. Lian, Y. Liu, J. Huang

This study develops a deep learning model to classify hematopoietic stem cells and multipotent progenitors using light microscopy images, demonstrating its effectiveness in distinguishing functional subpopulations.

bioRxiv · Dec 19, 2022 · PreprintBioengineering

ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination

H. Li, S. Chatla, X. Liu, Z. Tian, U. Vekariya, P. Wang, D. Kim, S. Octaviani, Z. Lian, G. Morton, Z. Feng, D. Yang, K. Sullivan-Reed, W. Childers, X. Yu, , J. Huang

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

bioRxiv · Sep 29, 2022 · PreprintCancer Biology

Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat generated by CRISPR/Cas9

M. Wang, Y. Qi, Y. Cao, X. Zhang, Y. Wang, J. Zhang, Q. Liu, Q. Zhou, Y. Ai, S. Wei, L. Wang, G. Liu, Z. Lian, H. Han

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

bioRxiv · Mar 10, 2022Immunology

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

A. R. Cox, P. M. Masschelin, P. Saha, J. B. Felix, R. Sharp, Z. Lian, Y. Xia, N. Chernis, D. A. Bader, K. H. Kim, X. Li, J. Yoshino, X. Li, Z. Sun, H. Wu, , S. M. Hartig

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

bioRxiv · Sep 11, 2021 · PreprintPhysiology

STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

A. R. Cox, N. Chernis, D. A. Bader, P. Saha, P. M. Masschelin, J. B. Felix, Z. Lian, V. Putluri, K. Rajapakshe, K. H. Kim, D. T. Villareal, R. Armamento-Villareal, H. Wu, C. Coarfa, N. Putluri, S. M. Hartig

The paper investigates how STAT1 activity in adipocytes affects insulin sensitivity in obesity, finding that STAT1 deletion improves mitochondrial function but does not resolve insulin resistance.

bioRxiv · Apr 10, 2020Immunology