ImmunologybioRxiv
Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling
M. Goepp, S. Crittenden, Y. Zhou…·C. Yao
This study shows PGE2 inhibits inducible Treg cell differentiation via EP2 and EP4 receptors by blocking TGF-β signaling in vitro and in vivo.