C. Yao

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Identification of Lactuca sativa transcription factors impacting resistance to Botrytis cinerea through predictive network inference

The paper identifies transcription factors in lettuce that influence resistance to Botrytis cinerea by inferring gene regulatory networks from time-series expression data.

A transcriptional cell atlas identifies the decline in the AT2 niche in aged human lungs

This study creates a single-cell transcriptional atlas of human lungs across ages, revealing age-related dysregulation in AT2 cells and their niche, including increased senescence and inflammation.

"Double-Effect" strategy against Triple-Negative Breast Cancer via a synergistic therapy of Magneto-mechanical Force enhancing NIR-II Hypothermal Ablation

This paper develops a synergistic therapy for triple-negative breast cancer using magneto-mechanical force and NIR-II hypothermal ablation to suppress tumor migration and invasion.

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

This paper introduces a genetically encoded tool to increase the NADH/NAD+ ratio in mammalian cells and characterizes its metabolic and transcriptomic effects.

Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens

The paper identifies genetic loci in lettuce conferring quantitative resistance to fungal pathogens and predicts molecular mechanisms through transcriptome profiling.

Impact of cell culture on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells

This study compares the transcriptomes of primary, cultured, and iPSC-derived human alveolar type 2 cells to assess how culture affects their gene expression profiles and maturation states.

Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses

This study identifies that PGE2-EP2 signaling suppresses lung ILC2 responses and eosinophilic inflammation, while EP4 agonism restricts these responses, offering potential therapeutic targets for asthma and NERD.

Cryobanking of human distal lung epithelial cells for preservation of their phenotypic and functional characteristics.

This study describes a cryobanking method that preserves phenotypic and functional characteristics of human distal lung epithelial cells, including alveolar type 2 pneumocytes.

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral Infection.

This study shows that epithelial plasticity and innate immune activation contribute to lung tissue remodeling after viral infection, protecting against mortality but causing long-term lung dysfunction.

Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling

This study shows PGE2 inhibits inducible Treg cell differentiation via EP2 and EP4 receptors by blocking TGF-β signaling in vitro and in vivo.

Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary Fibrosis

The paper identifies a zinc metabolic defect in alveolar progenitor cells in IPF and aged mice, linked to impaired renewal and fibrosis through ZIP8 downregulation.

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

Recombinant HcGAPDH Protein Expressed on Probiotic Bacillus subtilis Spores Protects Sheep from Haemonchus contortus Infection by Inducing both Humoral and Cell-mediated Responses

This paper shows that recombinant Bacillus subtilis spores expressing H. contortus GAPDH protect sheep from infection by boosting immune responses and reducing parasite burden.

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

The paper develops a primary human lung epithelium infection model to study SARS-CoV-2 pathobiology and screen drugs for COVID-19.

Single cell reconstruction of human basal cell diversity in normal and IPF lung.

The paper uses single-cell RNA sequencing to analyze basal cell diversity in normal and IPF lung, finding increased secretory primed basal cells in IPF and roles for NOTCH2 and NOTCH3 in their regulation.

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis

The paper uses single-cell transcriptomics to analyze proximal airway epithelium in CF and healthy donors, identifying molecular changes linked to CF pathogenesis.

Senescence of alveolar stem cells drives progressive pulmonary fibrosis

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.

Mutant p53 Drives Clonal Hematopoiesis through Modulating Epigenetic Pathway

This study identifies mutant p53's role in promoting clonal hematopoiesis by modulating the EZH2-mediated epigenetic pathway.

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.

Establishment of baseline sensitivity of Rhizoctonia solani to thifluzamide in corn and its field application

This paper evaluates the sensitivity of Rhizoctonia solani to thifluzamide in corn and assesses the effectiveness of seed coating with thifluzamide suspension agent in improving physiological indicators and controlling banded leaf sheath blight.