J. Zeng

Evaluation of the efficacy of the protopine total alkaloids of Macleaya cordata (Willd.) R. Br. in controlling E. coli infection in broiler chickens

This study evaluates the effectiveness of MPTA extract in reducing E. coli mortality and promoting recovery in infected chickens, finding that 400-1600 mg/kg MPTA-P over 7 days is most effective.

Unveiling the mechanisms of black phosphorus nanosheets-induced viable but non-culturable state in Bacillus tropicus

This study investigates how black phosphorus nanosheets induce a viable but non-culturable state in Bacillus tropicus, revealing suppressed metabolism and respiratory pathways as key mechanisms.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

The synergistic effects of plants and nitrogen on microbial hitchhiking

The paper investigates how plants and nitrogen fertilizer influence microbial hitchhiking, finding that their synergy affects soil microbiome composition and function depending on nitrogen levels.

Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets

This study develops stabilized Cas-embedded base editors (sCE_CBEs) that enable efficient and accurate C-to-T editing with minimal off-target effects in hematopoietic stem and progenitor cells.

Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

This paper introduces Ingenui-T, a method for rapid CAR T-cell manufacturing from whole blood, showing comparable or better functional activity than conventional methods.

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

A Computational Framework for the Administration of 5-Aminovulinic Acid before Glioblastoma Surgery

The paper develops a computational framework to simulate 5-ALA transport and fluorescence in glioblastoma patients, showing peak fluorescence occurs 2-7 hours post-administration, consistent with current guidelines.

Nitric Oxide controls shoot meristem activity via regulation of DNA methylation

This study shows that nitric oxide regulates DNA methylation in Arabidopsis shoot meristems by modulating AGO4 activity and its interaction with the WUSCHEL transcription factor.

Widely naturalized species are not more promiscuous in the use of different nitrogen forms, but benefit more from inorganic nitrogen

The study finds that widely naturalized plant species do not show greater promiscuity in nitrogen form use but benefit more from inorganic nitrogen, suggesting this trait may contribute to their naturalization success.

PQS and pyochelin in Pseudomonas aeruginosa share inner membrane transporters to mediate iron uptake

This study identifies shared inner membrane transporters for PQS-Fe3+ and PCH-Fe3+ in P. aeruginosa and shows their role in iron uptake and virulence.

The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability

This study identifies STUB1 as a tumor suppressor in ccRCC by promoting YTHDF1 degradation, with low STUB1 expression linked to poor patient outcomes.

Synergistic activity of rhamnolipid combined with linezolid against linezolid-resistant Enterococcus faecium

This study shows that rhamnolipids combined with linezolid synergistically enhance antibacterial activity against linezolid-resistant Enterococcus faecium through multiple assays and mouse models.

Acidic nanoparticles restore lysosomal acidification and rescue metabolic dysfunction in pancreatic β-cells under lipotoxic condition

This study develops TFSA nanoparticles that restore lysosomal acidification and improve metabolic function in pancreatic β-cells under lipotoxic conditions.

Tirzepatide inhibits tumor growth in mice with diet-induced obesity

Tirzepatide reduces tumor growth in obese mice by decreasing food intake and metabolic hormones, but not by directly inhibiting cancer cell proliferation.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer

This paper develops a mouse model to study the pre-malignant progression of basal-like breast cancer, revealing stepwise lesion development and spatially resolved mutant cell analysis.

A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

The N-terminal subunit of vitellogenin in planthopper eggs and saliva acts as a reliable elicitor that induces defenses in rice

This study shows that the N-terminal subunit of vitellogenin from planthoppers induces defense responses in rice, reducing egg hatching and attracting parasitoids.

Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcoma

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.

Effective infection with dengue virus in experimental neonate and adult mice through intranasal route

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

Impact of various vaccine boosters on neutralization against Omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

Quantitative clonal analysis reveals vast heterogeneity among fallopian tube cells for ovarian cancer-initiation and progression

This study uses quantitative clonal tracing in mice to show that only a rare subset of distal fallopian tube cells can initiate and progress serous ovarian cancer.

FoQDE2-dependent milRNA promotes Fusarium oxysporum f. sp. cubense virulence by targeting a glycosyl hydrolase coding gene at transcriptional level

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

Isolation, identification and molecular characterization of Aeromonas spp. from farmed loach (Misgurnus anguillicaudatus)

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

Why are SNAREpins rod-shaped?

This study uses simulations to show rod-shaped SNAREpins are necessary for efficient membrane fusion via entropic forces.

Host cell membrane capture by the SARS CoV-2 spike protein fusion intermediate

This study models the SARS-CoV-2 spike protein fusion intermediate (FI) to understand its membrane capture mechanism and suggests potential drug targets.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase

This study screens a chemical library to identify SARS-CoV-2 RdRp inhibitors, finding three novel compounds and confirming suramin-like compounds as inhibitors.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease

This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.