Glomerular Elastic Modulus and Gene Expression PatternsDefine Two Phases of Alport Nephropathy
J. Yoon, Z. Liu, M. Alaba, L. A. Bruggeman, P. Janmey, C. Arana, O. Ayenuyo, I. Medeiros, S. Eddy, M. Kretzler, J. M. Henderson, V. Nair, A. Naik, A. N. Chang, R. T. Miller
This study identifies early glomerular changes and gene expression patterns in Alport syndrome, showing ER stress and four genes as key drivers of disease before proteinuria, and highlights potential therapeutic targets.
bioRxiv · Feb 26, 2024 · PreprintCell Biology