V. Chen

Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

Post-Transplant Administration of G-CSF Impedes Engraftment of Gene Edited Human Hematopoietic Stem Cells by Exacerbating the p53-Mediated DNA Damage Response

This study shows that post-transplant G-CSF administration impairs engraftment of CRISPR-edited HSPCs by worsening the p53 DNA damage response, but not unedited or lentiviral-transduced HSPCs.

A Chloroplast Protein Atlas Reveals Novel Structures and Spatial Organization of Biosynthetic Pathways

The paper maps the localization of 1,032 chloroplast proteins in Chlamydomonas reinhardtii, revealing novel structures, spatial organization, and dual-organelle targeting.

Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress

The paper shows that adaptation delays in bacteria cause mutation bursts during oxidative stress, which can be mitigated by prior stress exposure or constitutive OxyR activation.

Chemoproteomics of microbiota metabolites reveals small-molecule agonists for orphan receptor GPRC5A

The paper identifies small-molecule agonists for the orphan receptor GPRC5A using chemoproteomics of microbiota metabolites, revealing bacterial sources and key residues involved in ligand binding.

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

RecT recombinase expression enables efficient gene editing in Enterococcus

This paper demonstrates that expressing RecT recombinase in Enterococcus species significantly improves gene editing efficiency using recombineering techniques.

Membrane Orientation and Oligomerization of the Melanocortin Receptor Accessory Protein 2

This study investigates the membrane orientation and dimerization of MRAP2, showing that its dimerization occurs through the transmembrane domain and forms higher-order oligomers.

Systematic Discovery of the Functional Impact of Somatic Genome Alterations in Individual Tumors through Tumor-specific Causal Inference

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.