HIV viral protein R induces loss of DCT1-type renal tubules
K. Z. Latt, T. Yoshida, S. Shrivastav, A. Abedini, J. M. Reece, Z. Sun, H. Lee, K. Okamoto, P. Dagur, J. Heymann, Y. Zhao, J.-Y. Chung, S. Hewitt, P. A. Jose, K. Lee, , J. B. Kopp
This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.
bioRxiv · Feb 2, 2023 · PreprintPathology