P. Loskill

Solid tumor-on-chip model for efficacy and safety assessment of CAR-T cell therapy

This paper presents a solid tumor-on-chip model to assess CAR-T cell therapy efficacy and safety, showing CAR-T cells exhibit enhanced tumor infiltration and cytokine release, with potential for patient stratification.

Engineering of human myotubes toward a mature metabolic and contractile phenotype

This paper shows that adding IGF1 to human myoblast cultures improves their contractility and metabolic profile, making them more like mature skeletal muscle.

Training the next generation of researchers in the Organ-on-Chip field

The paper identifies key training priorities for Organ-on-Chip researchers and highlights the need for transdisciplinary education across biology, engineering, and pharmacology.

Fusing spheroids to aligned μ-tissues in a Heart-on-Chip featuring oxygen sensing and electrical pacing capabilities

This paper introduces a Heart-on-Chip system using spheroids to generate aligned cardiac tissues with electrical pacing and oxygen sensing capabilities.

Aged human iPSC-RPE organoid cultures display hallmarks of drusen formation

This study develops an in vitro model of aged human iPSC-derived RPE organoids that display AMD-like features including drusen formation and age-related alterations.

Autologous human immunocompetent white adipose tissue-on-chip

This paper introduces a human-based, immunocompetent WAT-on-chip model that recapitulates adipose tissue heterogeneity and functions for metabolic research and personalized medicine.

Human immunocompetent Choroid-on-Chip: a novel tool for studying ocular effects of biological drugs

The paper develops a human immunocompetent Choroid-on-Chip model to study ocular effects of biological drugs and assess immunotoxicity.

Human stem cell-based retina-on-chip as new translational model for validation of AAV retinal gene therapy vectors

The paper evaluates seven AAV vectors using a human stem cell-derived Retina-on-chip model to assess their efficacy, kinetics, and cell tropism.

WAT’s up!? – Organ-on-a-chip integrating human mature white adipose tissues for mechanistic research and pharmaceutical applications

The paper develops a WAT-on-a-chip system to study human white adipose tissue function and drug responses in obesity and diabetes.

Human Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip Technology to Generate Complex Multi-Layer Tissue Models

This study develops a retina-on-a-chip model using hiPSC-derived retinal cells to recapitulate retinal interactions and test drug effects.