B. Warscheid

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

PEX39 facilitates the peroxisomal import of PTS2 proteins

This study identifies PEX39 as a cytosolic peroxin that facilitates PTS2-protein import by interacting with PEX7 and stabilizing its binding to cargo.

Integrative Omics reveals changes in the cellular landscape of yeast without peroxisomes

The paper compares transcriptomics and proteomics data from wild-type and peroxisome-deficient yeast to identify changes in cellular processes due to peroxisome loss.

Coordination of cytochrome bc1 complex assembly at MICOS

The paper identifies Mar26 as a determinant in cytochrome bc1 complex assembly, showing it connects assembly intermediates to MICOS to coordinate complex III maturation at crista junctions.

Intermembrane space-localized twin Cx9C motif-containing TbTim15 is an essential subunit of the single mitochondrial inner membrane protein translocase of trypanosomes

The paper identifies TbTim15 as an essential subunit of the trypanosome TIM complex, showing it mediates import of both presequence-containing and mitochondrial carrier proteins.

Evolutionary repurposing of trypanosomal Pam18 and Pam16 reveals a new regulatory circuit for mitochondrial genome replication

This study shows that TbPam16 and TbPam18 in Trypanosoma brucei regulate maxicircle replication in mitochondria through a novel regulatory circuit involving MaRF11 and proteasomal control.

High confidence glycosomal membrane protein inventory unveils trypanosomal Peroxin PEX15

The paper identifies 28 novel glycosomal membrane proteins in trypanosomes, validates four new ones, and identifies PEX15 as a key protein essential for glycosome biogenesis and parasite survival.

A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of trypanosomes

This study identifies a trypanosome Msp1-containing complex that removes orphaned mitochondrial outer membrane proteins through proteasomal digestion.

The Mba1 homologue of Trypanosoma brucei is involved in the biogenesis of oxidative phosphorylation complexes

This study shows that TbMba1 is essential for oxidative phosphorylation in procyclic trypanosomes but not in bloodstream forms, and identifies its role in Cox complex biogenesis.

Conformational dynamics and target-dependent myristoyl switch of calcineurin B homologous protein 3

This study investigates the conformational dynamics and target-dependent myristoyl switch of CHP3, revealing that Ca2+ binding and myristoylation independently regulate its function and membrane association.

Quantitative proteomics and lipidomics of TFG-deficient B cells provide insights into mechanisms of autophagic flux and plasma cell biology

This study uses proteomics and lipidomics to analyze TFG-deficient B cells, identifying TFG's role in autophagy, plasma cell biology, and lipid homeostasis.

MaxQuant and MSstats in Galaxy enable reproducible cloud-based analysis of quantitative proteomics experiments for everyone

The paper integrates MaxQuant and MSstats into Galaxy for reproducible cloud-based quantitative proteomics analysis, enabling accessible and transparent workflows for researchers.

Protein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress

The paper shows that mitochondrial stress increases proteasome activity via HSPB1 and PSMB9, which are regulated by EEF1A2 and localized near mitochondria to prevent protein aggregation.

Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β

This study identifies phosphorylation and GSK3β regulation of ACBD5-VAPB tethering, which controls peroxisome-ER contacts in mammalian cells.

Characterisation of a highly diverged mitochondrial ATP synthase peripheral stalk subunit b in Trypanosoma brucei

The paper identifies a 17 kDa mitochondrial protein in Trypanosoma brucei essential for growth and oxidative phosphorylation, showing structural similarity to subunit b of other species.

Mistargeting of hydrophobic mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes

This study shows that ablation of ATOM69 in Trypanosoma brucei triggers a nucleus-mediated quality control pathway leading to proteasomal degradation of mislocalized mitochondrial proteins.

The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei

This study identifies the TbEMC complex in Trypanosoma brucei, showing it localizes to the mitochondrial-ER interface and modulates phospholipid biosynthesis.

Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae

The paper identifies Ola1p as a positive regulator of heat shock response in yeast through proteomics and cell-based assays, showing its role in stabilizing misfolded proteins and facilitating translation resumption after stress.

Quantitative Proteomics Identifies PTP1B as Modulator of B Cell Antigen Receptor Signaling

The paper identifies PTP1B as a negative regulator of B cell antigen receptor signaling by dephosphorylating key receptor and downstream signaling components.

Molecular basis of F-actin regulation and sarcomere assembly via myotilin

This study reveals the structural dynamics of myotilin and its interaction with F-actin, showing how it stabilizes Z-discs and displaces tropomyosin.

Pex14p phosphorylation modulates import of citrate synthase 2 into peroxisomes in Saccharomyces cerevisiae

This study shows that phosphorylation of Pex14p at serine 266 regulates the import of Cit2p into peroxisomes, affecting yeast metabolism under different carbon sources.

Biogenesis of a mitochondrial DNA inheritance machinery in the mitochondrial outer membrane

The paper identifies a protein complex essential for mitochondrial DNA inheritance in Trypanosoma brucei and shows its biogenesis depends on conserved β-barrel assembly machinery.