Human microglia extensively reconstitute in humanized BLT mice with human interleukin-34 transgene and support HIV-1 brain infection
J. Zhang, S. C. Lohani, Y. Cheng, T. Wang, L. Guo, W.-K. Kim, S. Gorantla, Q. Li
This study shows human microglia can be reconstituted in the brain of hu-BLT mice with hIL34 transgene and support HIV-1 infection, highlighting their role in CNS HIV-1 pathogenesis.
bioRxiv · Feb 18, 2021Microbiology