S. Hebert

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

Satellite cell expansion is mediated by P-eIF2α dependent Tacc3 translation

This study shows that P-eIF2α-dependent translation of Tacc3 mRNA enables satellite cell expansion and skeletal muscle regeneration.