Author

A. Pacis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. P. Gomes· 1 shared A. Pause· 1 shared A. Poirier· 1 shared A. Robert· 1 shared C. Carli· 1 shared C. L. Kleinman· 1 shared C. Malouf· 1 shared C.-H. Feng· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. P. Gomes

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

I. E. Elkholi, A. Robert, C. Malouf, H. Kuasne, S. Drapela, G. Macleod, S. Hebert, A. Pacis, V. Calderon, C. L. Kleinman, A. P. Gomes, J. A. Aguirre-Ghiso, M. Park, S. Angers, J.-F. Cote

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

bioRxiv · Aug 2, 2023Cancer Biology

PTPN1/2 inhibition induces highly functional terminal effector CD8 T cells through autocrine IL-10

L. A. Perez-Quintero, A. Poirier, Z. Martinez-Cordoba, C.-H. Feng, I. Aubry, C. Carli, S. Kamyabiazar, A. Pacis, Y. Zolotarov, K.-A. Pike, J.-S. Delisle, M. L. Tremblay

This study shows that inhibiting PTPN1/2 enhances CD8 T cell effector function via autocrine IL-10, suggesting a new strategy for cancer immunotherapy.

bioRxiv · Apr 17, 2023 · PreprintImmunology

FLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model

M. Paquette, M. Yan, L. El-Houjeiri, M. Biondini, J. M. J. Ramirez-Reyes, A. Pacis, H. Jeong, J. L. Estall, P. M. Siegel, A. Pause

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

bioRxiv · Sep 10, 2020 · PreprintPathology