Author

G. MacLeod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:genetic perturbation / CRISPR· 4 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

S. Angers· 5 shared N. Rajakulendran· 4 shared Z. Steinhart· 3 shared F. J. Coutinho· 2 shared M. Ahmadi· 2 shared M. M. Kushida· 2 shared P. B. Dirks· 2 shared S. Weiss· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersCancer Biology

S. Angers

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

I. E. Elkholi, A. Robert, C. Malouf, H. Kuasne, S. Drapela, G. Macleod, S. Hebert, A. Pacis, V. Calderon, C. L. Kleinman, A. P. Gomes, J. A. Aguirre-Ghiso, M. Park, S. Angers, J.-F. Cote

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

bioRxiv · Aug 2, 2023Cancer Biology

The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.

M. Ahmadi, G. MacLeod, N. Rajakulendran, M. Kosic, A. Yang, F. Molaei, S. Lin, Z. Steinhart, N. I. Park, P. B. Dirks, S. Angers

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

bioRxiv · May 4, 2021 · PreprintCell Biology

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

P. Guilhamon, M. M. Kushida, A. Nikolic, D. Singhal, G. MacLeod, S. A. M. Tonekaboni, F. M. Cavalli, C. Arlidge, N. Rajakulendran, N. Rastegar, X. Hao, R. Hassam, L. J. Smith, H. Whetstone, F. J. Coutinho, , M. Lupien

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

bioRxiv · Mar 13, 2020 · PreprintCancer Biology

The functional genomic circuitry of human glioblastoma stem cells

G. MacLeod, D. A. Bozek, N. Rajakulendran, V. Monteiro, M. Ahmadi, Z. Steinhart, M. M. Kushida, H. Yu, F. J. Coutinho, I. Restall, X. Hao, T. Hart, H. A. Luchman, S. Weiss, P. B. Dirks, S. Angers

This study uses CRISPR-Cas9 screens in patient-derived glioblastoma stem cells to identify essential genes and pathways for stemness and drug resistance, revealing new therapeutic targets.

bioRxiv · Jun 28, 2018 · PreprintCancer Biology