Author

S. Hultgren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. J. L. Lynch· 1 shared A. Kau· 1 shared A. L. Flores-Mireles· 1 shared A. Rosen· 1 shared C. L. Obernuefemann· 1 shared C. Obernuefemann· 1 shared C. S. Westfall· 1 shared C. Tomera· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMicrobiology

A. J. L. Lynch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice

A. Rosen, M. Lint, D. Voelker, N. Gilbert, C. Tomera, J. Santiago Borges, M. A. Wallace, T. Hannan, C.-A. D. Burnham, S. Hultgren, A. Kau

This study shows that SLPI protects against acute UTI in mice and suggests SLPI is regulated in response to uropathogen exposure in women.

mBio · Feb 14, 2024Peer-reviewedImmunology

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection

Z. Zou, C. Obernuefemann, P. Singh, J. Pinkner, W. Xu, T. Nye, K. Dodson, F. Almqvist, S. Hultgren, M. Caparon

This study develops and tests GmPcides, dihydrothiazolo ring-fused 2-pyridone compounds, showing efficacy against Streptococcus pyogenes SSTI and biofilm formation.

bioRxiv · Jan 2, 2024 · PreprintMicrobiology

Defining the roles of pyruvate oxidation, TCA cycle, and mannitol metabolism in methicillin resistance Staphylococcus aureus urinary tract infection

R. Kulkarni, S. Paudel, S. Guedry, J. N. Walker, C. L. Obernuefemann, S. Hultgren

This paper identifies metabolic pathways critical for MRSA survival in urinary tract infections and suggests potential therapeutic targets.

bioRxiv · Oct 28, 2022 · PreprintMicrobiology

The commercial antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo

C. S. Westfall, A. L. Flores-Mireles, J. I. Robinson, A. J. L. Lynch, S. Hultgren, J. P. Henderson, P. A. Levin

This paper shows triclosan increases antibiotic tolerance in bacteria and reduces antibiotic efficacy in mice.

bioRxiv · Dec 5, 2018 · PreprintMicrobiology