B. Farrell

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

This paper expresses and functionally characterizes the oncogenic RTK FGFR3-TACC3 using cell-free protein expression, achieving significant kinase activity.

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

This paper determines the structure of the PfRCR complex using cryogenic-electron microscopy, revealing its modular architecture and interaction with erythrocyte receptors, which informs vaccine design.

Evaluating the differential expression of TAM family receptors and efferocytosis activities in differentiated and polarized THP-1 macrophage

This study evaluates TAM family receptor and efferocytosis activity in differentiated and polarized THP-1 macrophages to assess their suitability for efferocytosis assays.

Electromechanics and Volume Dynamics in Non-excitable Tissue Cells

This study investigates how cell volume in non-excitable tissue cells is regulated by membrane potential and ion concentrations, showing volume changes under different conditions.