Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor
H. Sun, S. He, L. Meng, Y. Wang, H. Zhang, Y. Liu, J. Wang, M. Tao, S. K. Barta, E. Dulaimi, H. Fung, J.-P. J. Issa, L.-Z. Zheng, Y. Zhang
This study shows that engineering CAR-T cells with CD103 improves their anti-tumor efficacy against E-cadherin positive tumors by enhancing infiltration, expansion, and persistence in vivo.
bioRxiv · Aug 6, 2019 · PreprintImmunology