S. Kale

Adaptive diversification through structural variation in barley

This study presents a barley pangenome revealing structural variation linked to traits like disease resistance and plant architecture, highlighting its role in adaptive evolution.

Mapping mechanical stress in curved epithelia of designed size and shape

The paper maps mechanical stress in engineered curved epithelial monolayers of controlled size and shape, showing size-independent stress increases and stress anisotropies in rectangular and ellipsoidal geometries.

Deep Learning Reveals How Cells Pull, Buckle, and Navigate Tissue-Like Environments

This paper introduces DLFM, a deep learning method to measure real-time cell forces in tissue-like environments, revealing new mechanical behaviors during migration and differentiation.

Differential Histone-DNA Interactions Dictate Nucleosome Recognition of the Pioneer Transcription Factor Sox

This study shows that Sox PTF recognizes nucleosomes through distinct histone-DNA interactions, with specific reading mechanisms at different superhelical locations.

Dosage of duplicated and antifunctionalized homeobox proteins influences spikelet development in barley

This study shows that the dosage of HvHOX1 and HvHOX2, two antagonistic homeobox transcription factors, influences spikelet development in barley.

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.