Author

B. Zhai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

M. Daugaard· 2 shared A. A. Mishra· 1 shared A. D. Luster· 1 shared A. Djukovic· 1 shared A. Jhingran· 1 shared A. Rivera· 1 shared A. Sathaseevan· 1 shared A. Subramanian· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

M. Daugaard

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Enhancing anti-gastrointestinal cancer activities of CLDN18.2 CAR-T armored with novel synthetic NKG2D receptors Containing DAP10 and DAP12 signaling domains.

M. Sun, H. Wang, R. Hao, Y. Wang, Y. Li, Y. Zhong, S. Zhang, B. Zhai, Y. Cheng

This paper develops a CAR-T therapy for gastrointestinal cancers by combining CLDN18.2 targeting with synthetic NKG2D receptors containing DAP10 and DAP12 domains, improving efficacy against heterogeneous tumors.

bioRxiv · May 17, 2023 · PreprintImmunology

A bi-functional PARP-HDAC inhibitor with activity in Ewing sarcoma

L. Ramos, S. Truong, B. Zhai, J. Joshi, F. Ghaidi, M. M. Lizardo, T. Shyp, H. Adomat, S. LeBihan, C. C. Collins, J. Bacha, D. Brown, J. Langlands, W. Shen, N. Lallous, , M. Daugaard

This paper develops a dual PARP and HDAC inhibitor, kt-3283, showing enhanced cytotoxicity and efficacy in Ewing sarcoma models compared to single-agent inhibitors.

bioRxiv · Nov 10, 2022 · PreprintCancer Biology

A High Fraction of Oral Bacteria in the Feces Indicates Gut Microbiota Depletion with Implications for Human Health

C. Liao, T. Rolling, A. Djukovic, T. Fei, V. Mishra, H. Liu, C. Lindberg, L. Dai, B. Zhai, J. U. Peled, M. R. M. van den Brink, T. M. Hohl, J. B. Xavier

The paper investigates the association between oral bacteria in feces and gut microbiota depletion, supporting the Marker hypothesis over the Expansion hypothesis.

bioRxiv · Oct 24, 2022Microbiology

Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract

L. McDonough, A. A. Mishra, N. Tosini, P. Kakade, S. Penumutchu, S.-H. Liang, C. Maufrais, B. Zhai, Y. Taur, P. Belenky, R. J. Bennett, T. J. Hohl, A. Y. Koh, I. V. Ene

This study identifies two Candida albicans isolates that stably colonize the murine gastrointestinal tract, revealing strain-specific differences in colonization and host antimicrobial peptide sensitivity.

bioRxiv · Jun 27, 2021Microbiology

Alternative polyadenylation is a determinant of oncogenic Ras function

A. Subramanian, M. Hall, H. Hou, M. Mufteev, B. Yu, K. E. Yuki, H. Nishimura, A. Sathaseevan, B. Lant, B. Zhai, J. Ellis, M. D. Wilson, M. Daugaard, W. B. Derry

This study shows that alternative polyadenylation regulates oncogenic Ras function by affecting transcript 3' UTR length in both C. elegans and human cells.

bioRxiv · Jun 8, 2020Cancer Biology

During Aspergillus infection, neutrophil, monocyte-derived DC, and plasmacytoid DC enhance innate immune defense through CXCR3-dependent crosstalk

Y. Guo, S. Kasahara, A. Jhingran, N. L. Tosini, B. Zhai, M. A. Aufiero, K. A. M. Mills, M. Gjonbalaj, V. Espinosa, A. Rivera, A. D. Luster, T. Hohl

The paper shows that pDCs enhance innate immune defense against Aspergillus by amplifying neutrophil activity through CXCR3-dependent crosstalk during infection.

bioRxiv · May 5, 2020Immunology

Host carbon dioxide concentration is an independent stress for Cryptococcus neoformans that affects virulence and antifungal susceptibility

D. J. Krysan, B. Zhai, S. R. Beattie, K. M. Misel, M. Wellington, X. Lin

This study identifies CO2 tolerance as a virulence trait in Cryptococcus neoformans, linking it to disease severity and antifungal drug susceptibility.

bioRxiv · Jun 4, 2019Microbiology