LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility
J. Y. Hwang, P. Chai, S. Nawaz, J. Choi, F. Lopez-Giraldez, S. Hussain, K. Bilguvar, S. Mane, R. P. Lifton, W. Ahmad, K. Zhang, J.-J. Chung
This study identifies LRRC23 as a critical component of the RS3 head in mammalian sperm, showing that its truncation leads to defective flagellar motility and male infertility.
eLife · Dec 13, 2023Peer-reviewedCell Biology