Human vascular organoids with a mosaic AKT1 mutation recapitulate Proteus syndrome
S. He, Y. Zhu, S. Chauhan, D. N. Tavakol, J. H. Lee, R. B.-L. Berris, C. Xu, J. Lee, C. Lee, S. Cai, S. McElroy, G. Vunjak-Novakovic, R. Tomer, E. Azizi, B. Xu, , K. W. Leong
This paper creates a vascular organoid model with an AKT1 mutation to study Proteus syndrome and finds AKT inhibitors reverse vascular malformations.
bioRxiv · Jan 26, 2024 · PreprintBioengineering